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ÁßÃ߽Űæ°èÅëÀÌ Á¤»óÀû ±â´ÉÀ» ¼öÇàÇϱâ À§Çؼ´Â ¸Å¿ì ¾ÈÁ¤µÈ ȯ°æÀ» ÇÊ¿ä·Î ÇÑ´Ù. ÀÌ ¾ÈÁ¤¼ºÀº Ç÷³úÀ庮(blood-brain barrier, BBB)°ú Ç÷¾×¼ö¾×À庮(blood-cerebrospinal fliud barrier)¿¡ ÀÇÇØ ½Å°æ°èÅëÀÌ Ç÷¾×À¸·ÎºÎÅÍ °Ý¸®µÊÀ¸·Î½á À¯ÁöµÈ´Ù.
1. ³úÇ÷°üÀ庮 (Blood-brain barrier)
Ç÷³úÀ庮ÀÇ ±¸Á¶¸¦ º¸¸é ÁßÃ߽Űæ°èÀÇ ¸ð¼¼Ç÷°üÀÇ ³»°°ú ½Å°æÁ¶Á÷ »çÀÌ¿¡´Â ´ÙÀ½°ú °°Àº ±¸Á¶¹°µéÀÌ °³ÀçµÇ¾î ÀÖ´Ù.
¸ð¼¼Ç÷°ü(capillary)ÀÇ ³»ÇǼ¼Æ÷(endothelium), ³»ÇǼ¼Æ÷ÀÇ ¹ÛÀ» ¿¬¼ÓÀûÀ¸·Î µÑ·¯½Î´Â ±âÀú¸·(basement membrane), º°¾Æ±³¼¼Æ÷ÀÇ ¹ßµ¹±â(end feet)µéÀÌ´Ù.
ÀÌ ±¸Á¶µé ¸ðµÎ°¡ Ç÷³úÀ庮À» Á¶ÀýÇϰí ÀÖÁö¸¸ ƯÈ÷, ÁßÃ߽Űæ°èÀÇ ³»ÇǼ¼Æ÷¿¡´Â Æ÷À½¼ÒÆ÷(pinocytotic vesicle)°¡ °ÅÀÇ Á¸ÀçÇÏÁö ¾ÊÀ¸¸ç, ³úÀÇ ³»ÇǼ¼Æ÷»çÀÌ¿¡´Â Æó¼â¶ì(tight junction)°¡ Á¸ÀçÇÑ´Ù´Â °ÍÀÌ Ç÷³úÀ庮À» À¯¹ßÇÏ´Â °¡Àå ÁÖµÈ ±¸¼º ¿ä¼Ò·Î ¿©°ÜÁö°í ÀÖ´Ù.
Ç÷³úÀ庮À» ÅëÇÑ ¹°ÁúÀ̵¿Àº È®»ê(diffusion), ¿î¹Ýü¸Å°³À̵¿(carrier-mediated transport), ´Éµ¿¼ö¼Û(active transport)À» ÅëÇØ ÀÌ·ç¾îÁø´Ù.
Barbiturate, heroin, alcohol µîÀÇ ¹°ÁúÀº ÁöÁúÀÇ ¿ëÇØµµ¿Í ºñ·ÊÇÏ¿© È®»ê¿¡ ÀÇÇØ Ç÷³úÀ庮À» Åë°úÇÑ´Ù.
D-glucose¿Í ½Å°æÀü´Þ¹°ÁúÀÇ ÇÕ¼º¿¡ ÇÊ¿äÇÑ ¸î °¡Áö ¾Æ¹Ì³ë»êÀº ¿î¹Ýü¸Å°³À̵¿¿¡ ÀÇÇØ Ç÷³úÀ庮À» Åë°úÇÑ´Ù.
ÀÌ·¯ÇÑ Ç÷¾×°ú ³ú »çÀÌÀÇ °ü¹®Àº ³úÀÇ ¸ðµç ºÎÀ§¿¡¼ ´Ù ¿ÏÀüÇÑ °ÍÀº ¾Æ´Ï´Ù.
¼Û°úü(pineal gland), ³ú±Ã¾Æ·¡±â°ü(subfornical organ), Á¾¸»ÆÇÇ÷°ü±â°ü(organum vasculosum of lamina terminalis), ½Ã»óÇϺΠ(hypothalamus), Á¤ÁßÀ¶±â(median eminence), ½Å°æ³úÇϼöü(neurohypophysis), ¸Å¾Æ·¡±¸¿ª(area postrema) µîÀÇ ³ú½ÇÁÖÀ§±â°ü (circumventricular organ)¿¡¼´Â Æó¼â¶ì¸¦ °¡Áø ¸ð¼¼Ç÷°ü ´ë½Å¿¡ À¯Ã¢¸ð¼¼Ç÷°ü(fenestrated capillary)À¸·Î µÇ¾î ÀÖ¾î¼, Ç÷³úÀ庮ÀÌ Á¸ÀçÇÏÁö ¾Ê´Â ºÎÀ§ÀÌ´Ù.
2. Ç÷¾×-³úô¼ö¾× °ü¹®(Blood-cerebrospinal fluid barrier)
³úô¼ö¾×(CSF)À» »ý¼ºÇÏ´Â ¸Æ¶ô¾ó±â(choroid plexus)¿¡´Â ¸ð¼¼Ç÷°üÀÌ ÀÖÀ¸¸ç, ±× ¸ð¼¼Ç÷°ü ³»ÀÇ Ç÷¾×°ú ³úô¼ö¾×Àº ¼·Î ´Ù¸¥ ³óµµÀÇ ÀüÇØÁú µîÀ» ÇÔÀ¯Çϰí ÀÖ´Ù.
¸Æ¶ô¾ó±âÀÇ ¸ð¼¼Ç÷°üÀ» Á¶»çÇØ º¸¸é, À¯Ã¢¸ð¼¼Ç÷°üÀÌ´Ù. µû¶ó¼, Ç÷¾×°ú CSF »çÀÌ¿¡¼ ´Ü¹éÁú°ú ¿ëÁú¿¡ ´ëÇÑ °ü¹®Àº ¸Æ¶ô¾ó±â¿¡ Á¸ÀçÇÏ´Â ¸ð¼¼Ç÷°üÀÌ ¾Æ´Ï¶ó, ³ú½ÇÀÇ ³»°°ú Á¢ÇØ ÀÖ´Â ¸Æ¶ô»óÇǼ¼Æ÷(choroid epithelial cell) »çÀÌÀÇ Æó¼â¶ì¿¡ ±âÀÎÇÑ´Ù.
´Ü¹éÁú ÃßÀûÀÚ¿Í Æ¯Á¤ È¿¼Ò¸¦ Á¤¸Æ ³»·Î ÁÖ»çÇÏ¿´À» ¶§, ¸Æ¶ô¾ó±âÀÇ ¸ð¼¼Ç÷°ü âÀ» ÅëÇÏ¿© ¸Æ¶ô¾ó±âÀÇ ¹ÙÅÁÁú(stroma)·Î´Â µé¾î°¡³ª, ¸Æ¶ô»óÇǼ¼Æ÷ °£ÀÇ Æó¼â¶ì´Â Åë°úÇÏÁö ¸øÇϹǷΠCSF¿¡ µé¾î°¡Áö ¸øÇÑ´Ù.