베타락탐항생제-세포벽 합성억제제

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Penicillins, Cephalosporins, etc.

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Penicillins, Cephalosporins, etc.



- these drugs are known as beta-lactams since they share a four-membered beta-lactam ring





- mechanisms of beta-lactam action are more complex than previously thought





- penicillin and cephalosporin appear to be analogs of a natural structural unit (D-alanyl-D-alanine) in the cell walls of many bacteria





- these antibiotics become covalently linked to the cell's penicillin-binding proteins (PBP's) which are the enzymes responsible for constructing or modifying the bacterial cell wall





- this binding to PBP's inhibits or prevents cross-linking of the cell wall structure and caused increased cell permeability, leakage and death





- there is also evidence for triggering of an active enzymatic process which leads to degradation of the cell wall





- penicillin is the best example of a cell wall active drug